This episode of Beats Radio, hosted by Danyaal Ansari, written by Shay Patel, produced by Hasssan Taleb, and edited by Anas Khoja, features an in-depth discussion with immunology expert Dr. Michele Ardolino from the University of Ottawa and the Ottawa Hospital Research Institute. The conversation centers around the fascinating interplay between the immune system and cancer, with a particular focus on the process of trogocytosis and its role in immune evasion by cancer cells. Dr. Ardolino elaborates on his groundbreaking research into how cancer cells transfer PD-1 to Natural Killer (NK) cells via trogocytosis, effectively inhibiting these critical components of the immune response. This detailed exploration sheds light on the sophisticated mechanisms cancer cells employ to evade immune detection and opens up discussions about potential therapeutic strategies targeting these interactions.
https://www.ohri.ca/profile/mardolino/cancer-immunology-lab
0:00 - Introduction
0:57 - Trogocytosis Explained
2:51 - Choosing Trogocytosis for PD-1 Transfer Study
5:00 - NK Cells' Functional Variability
8:10 - Immune System's Complexity & Beauty
10:50 - Rapid Fire Q&A
14:27 - Closing Remarks
Podcast by Danyaal Ansari (Host), Shay Patel (Writer), Hasssan Taleb (Producer), Anas Khoja (Editor)
Music by "Podcast Background Music" https://www.youtube.com/watch?v=cdFqvdekuvI