Unlocking the Mystery of Ovarian Cancer

Maheen Khanotia from the Translational Molecular Medicine program interviews Dr. Barabara Vanderhyden, a distinguished researcher at the Ottawa Hospital and a professor at the University of Ottawa. She is a leading researcher in ovarian cancer, focusing on the BRCA1 and BRCA2 mutations. In this podcast, Maheen discusses with Dr. Vanderhyden her key findings in her 2023 paper "BRCA1 and BRCA2 deficient tumor models generate distinct ovarian tumor microenvironments and differential responses to therapy," where they delve into the world of cancer, Dr. Vanderhyden's lab findings, potential treatments, and research advice.

Learn more:  https://www.ohri.ca/profile/vanderhydenlab/profile

0:05 | BEaTS and host introduction.
1:17 | Introduction to Dr. Barbara Vanderhyden.
1:39 | How did you come to study ovarian cancer?
2:48 | What led you to believe the BRCA1 and BRCA2 mutations are different?
3:50 | What is the tumor microenvironment?
4:57 |  What do the research findings mean to the general public?
6:05 | Why do BRCA1 and BRCA2 deletions at the gene and protein levels have different effects on tumor microenvironments?
8:04 | What were the challenges you went through as a researcher?
9:18  | What were the crucial limitations of your research?
10:24  | What are the future steps for ovarian cancer research?
11:56  | What is general advice you would give to other researchers?
12:55  | How long does a study like this take?
13:40  | How does this research affect a patient's diagnosis?
14:31  | Closing remarks

Credits for music: Soundtracks by the Underground Drive. All rights reserved. Listen more

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Maheen Khanotia (Voice, host, editor), Soniya Agarwal (Producer, writer)

Chapters

• 0:05 BEaTS and host introduction
• 1:17 Introduction to Dr. Barbara Vanderhyden
• 1:39 How did you come to study ovarian cancer?
• 2:48 What led you to believe the BRCA1 and BRCA2 mutations are different?
• 3:50 What is the tumor microenvironment?
• 4:57 What do the research findings mean to the general public?
• 8:04 What were the challenges you went through as a researcher?
• 9:18 What were the crucial limitations of your research?
• 10:24 What are the future steps for ovarian cancer research?
• 11:56 What is general advice you would give to other researchers?
• 13:40 How does this research affect a patient's diagnosis?