Building Barriers: Replicating the Brain's Shield Artwork

BEaTS Research Radio's Podcast

Each week on BEaTS Research Radio at the University of Ottawa Heart Institute, early-career scientists and investigators deep dive into the ever-changing, rapidly evolving world of Science in one-on-one conversations with some of the planet's most brilliant Scientists, breaking down the science in terms you can understand

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BEaTS Research Radio's Podcast

Building Barriers: Replicating the Brain's Shield

December 05, 2024 • BEaTS Research Radio • Season 1 • Episode 190

Maryam Yassin from the University of Ottawa interviews Dr. Anna Jezierski and Dr. Alex MacKenzie. Dr. Jezierski is a research officer at the Department of Translational Biosciences in the Human Health Therapeutics Research Center at the National Research Council of Canada. She is also an adjunct professor for the Department of Biochemistry, Microbiology, and Immunology at the University of Ottawa. In this episode, Dr. Jezierski shares her research on modeling the human blood-brain barrier using induced pluripotent stem cells and the various applications of this model in studying therapeutics for diseases of the central nervous system. We're also joined by Dr. Alex Mackenzie, an attending pediatrician and senior scientist at the Children's Hospital of Eastern Ontario (CHEO). He has served as the CEO and Scientific Director of CHEO Research Institute and is a cross-appointed member of the Faculty of Medicine at the University of Ottawa. Dr. Mackenzie comments on how this model is revolutionizing drug development.

Learn more: https://www.uottawa.ca/faculty-medicine/dr-anna-jezierski
https://www.cheoresearch.ca/research/find-a-researcher/alex-mackenzie/

0.03 | BEaTS and host introduction.
0.26 | Introduction to Dr. Jezierski.
1.17 | Introduction to Blood-Brain Barrier (BBB).
3.22 | Creating a BBB model using induced pluripotent stem cells is important.
7.07 | How tight junctions are replicated effectively.
9.20 | Applications of the iPSC-derived BBB model.
12.35 | Introduction to Dr. Alex Mackenzie
12.51 | Implications of the model on drug discovery and clinical trials.
14.54 | Closing remarks.

Soundtracks by the Underground Drive. All rights reserved. Listen more
https://www.dropbox.com/scl/fo/yrgjajtxzy4j08zj5iptc/AF7HMueoQwogLQMFxHxSHpU?e=1&preview=BEaTS+-+music+only+2.wav&rlkey=epcpj63eohwgi44mnqg7ctoa6&st=bn1v69ik&dl=0

Maryam Yassin (Voice), Aysha Aftab (Post-Production), Dalia Zeidan (Content Generation), Jordan Yin (Producer).