Sphingosine Kinase (SK) Inhibition: Ambushing the Ambush

Omar Moghrabi from the University of Ottawa interviews Dr. Marceline Côté about using Sphingosine Kinase (SK) Inhibitors to treat enveloped viruses like Ebola. Dr. Côté is an associate professor at the University of Ottawa and the director of the Centre for Infection, Immunity, & Inflammation, where her research and practice involve antiviral treatments. In this episode, Dr. Côté weighs in on the emerging research that suggests that the use of SK inhibitors may be the future of broad-spectrum antiviral treatments. Omar and Dr. Côté discuss the mechanism, breadth, and safety of SK inhibitors in detail and the future of this post-entry approach to viral combat.


Learn more: https://www.uottawa.ca/faculty-medicine/dr-marceline-cote

0:03 | Introduction to the speaker
1:04 | Lay Summary/intro to the topic
1:54 | How do viruses like Ebola enter cells in the first place?
4:50 | What are sphingosine kinases, and why are they such a good target for blocking viruses?
6:00 | How effective is this approach across these viruses, and were there any surprises or interesting findings?
8:48 | The future of broad-spectrum antiviral treatments and the potential of SK inhibitors
10:22 | Known side effects of using SK inhibitors and safety concerns
11:54 | Impact of SK Inhibitor Therapies on Public Health Responses During Viral Outbreaks
13:16 | Outro and Thanks

Intro: Sunny Brazilian Bossa Nova Jazz Podcast - Denis-Pavlov-Music;
Outro: Context Sensitive - CHIPTUNE
https://www.youtube.com/ContextSensitive
https://contextsensitive.bandcamp.com/

Producer: Zaid Taweel
Editor: Zaid Taweel
Script Writers and Editors: Aws Almir Ahmad and Paul Al Haddad
Show Host: Omar Moghrabi

Chapters

• 0:03 Introduction to the speaker
• 1:04 Lay Summary / intro to the topic
• 1:54 How do viruses like Ebola enter cells in the first place?
• 4:50 What are sphingosine kinases, and why are they such a good target for blocking viruses?
• 6:00 How effective is this approach across these viruses and were there any surprises or interesting findings?
• 8:48 The future of broad spectrum antiviral treatments and the potential of SK inhibitors
• 11:54 Impact of SK inhibitor therapies on public health responses during viral outbreaks